4.5 Defective phosphorylation of the interleukin 18 receptor beta-chain causes impaired NK cell function in systemic onset Juvenile Idiopathic Arthritis
نویسندگان
چکیده
Systemic onset Juvenile Idiopathic Arthritis (SoJIA) is an autoimmune disease characterised by arthritis and systemic features. Cytokines like IL1, IL6 and IL18 are thought to be responsible for clinical symptoms. IL18 can drive NK cell function. Recently we showed high IL18 levels in plasma correlate with disease activity in SoJIA [1]. Since SoJIA patients have diminished NK cell function we investigated the functionality of these cells in relation to IL18.
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